Guesthouse vacation rentals in James Island
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Top-rated guesthouse rentals in James Island
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for James Island guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Charleston
4.93 out of 5 average rating, 320 reviewsCozy Island Cottage
Guesthouse in Charleston
4.99 out of 5 average rating, 264 reviewsSpacious Daniel Island Apartment
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 217 reviewsBungalow Under The Oaks
Guesthouse in Summerville
4.98 out of 5 average rating, 651 reviews★Delightful guest house near historic plantations★
Guesthouse in North Charleston
4.94 out of 5 average rating, 350 reviewsCozy Park Circle, Charleston Guest House
Guesthouse in North Charleston
5.0 out of 5 average rating, 113 reviewsThe Park Circle Clerestory Studio Guest House
Guesthouse in Johns Island
4.98 out of 5 average rating, 242 reviewsPrivate waterfront apt in the oaks
Guesthouse in Charleston
4.84 out of 5 average rating, 112 reviewsRomantic Beach Style Cottage close to everything!
Guest house rentals with a patio
Guesthouse in Charleston
4.96 out of 5 average rating, 132 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Charleston
4.98 out of 5 average rating, 128 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Johns Island
4.91 out of 5 average rating, 113 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Charleston
4.82 out of 5 average rating, 97 reviewsGuest Suite by the Beach
Guesthouse in Charleston
5.0 out of 5 average rating, 26 reviews1/1 sleeps 3 ADU Modern+Amazing!
Guesthouse in Charleston
4.98 out of 5 average rating, 49 reviewsCountry in the City, "The Outback"
Guesthouse in Charleston
5.0 out of 5 average rating, 78 reviewsLuxury Loft (2 miles from Folly Beach)
Guesthouse in Charleston
5.0 out of 5 average rating, 16 reviewsGas Light Carriage House James Island
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.9 out of 5 average rating, 556 reviewsCute, Cozy, Charleston Cottage
Guesthouse in Charleston
4.99 out of 5 average rating, 210 reviewsRedesigned suite! 12min to city, pet-friendly
Guesthouse in Charleston
4.96 out of 5 average rating, 241 reviewsUnique Hidden Gem w/ Luxury Shower Near Folly & DT
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 413 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Guesthouse in Charleston
4.99 out of 5 average rating, 150 reviewsLarge Guesthouse with Private Dock & Marsh Views
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 225 reviewsCozy Apartment in Mount Pleasant
Guesthouse in Charleston
4.98 out of 5 average rating, 246 reviewsDetached Guest Suite
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 260 reviews#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!
Destinations to explore
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- Family travel hub Tips and inspiration
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- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes