Guesthouse vacation rentals in Port St. Lucie

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Popular amenities for Port St. Lucie guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
A serene salt-water pool is framed by lush greenery and palm trees. Two blue umbrellas provide shaded seating, while various lounge chairs are arranged nearby. The clear water reflects the vibrant surrounding foliage, creating a peaceful oasis for relaxation.
Guesthouse in Stuart
4.98 out of 5 average rating, 56 reviews

Hilton in-law Suite,10 min/Beach, 5 min to Town❤️

ReganRating, 5 stars5 days ago
Susan is such a friendly host. The place is just as described, and the location is great. Safe neighborhood, only a nine minute bike ride to the historic downtown area. The instructions to get inside were clear and easy. Even though the pool is a shared space, we rarely saw Susan, as she gave us our privacy. I liked how the bathroom had a side door to the private patio area with the propane fire pit. The bedroom is huge and the bed is super comfortable. There is also a shower which was convenient to use after returning from the beach. I would definitely recommend staying here. Oh yeah, I almost forgot to mention the chocolate croissants that were left for us upon our arrival. Delicious, and such a nice touch.
Guest favorite
A bright, open backyard features a circular pool with clear blue water, surrounded by a concrete deck. Two lounge chairs sit next to the pool, and an umbrella provides shade. The lush green lawn complements the bright sky with scattered clouds.
Guesthouse in Port St. Lucie
4.84 out of 5 average rating, 169 reviews

Serene Guesthouse | Saltwater Pool & Private Entry

AllieRating, 5 stars1 week ago
Perfect for a single person or a couple! It was very clean and had all the essentials! Bed was also very comfortable. The guest house had a beautiful aesthetic both inside and out. Thank you so much!!!
Superhost
The entrance features a black door adorned with a decorative sign, framed by greenery and twinkling string lights. A welcoming doormat sits on the stone pathway, leading to the inviting interior of the guest house.
Guesthouse in Palm City
4.97 out of 5 average rating, 60 reviews

Blue Mind -Waterfront Home’s Guest House w/Dockage

ChrisRating, 5 stars2 weeks ago
I booked the “Blue Mind” for a four week holiday in the Palm City / Stuart area. Fantastic property right on the water and directly across the channel from Stuart. Three kayaks are available to guests, all in excellent condition. The cottage itself is set back from the water behind the main house, but access to the water is easy. There’s parking for two cars, and the cottage is quiet and comfortable. Located on a cul-de-sac off of a cul-de-sac off of a cul-de-sac (no kidding!) in a quiet upscale residential area, it’s ideal for enjoying a walk around the neighborhood in the cool of the evening. On top of all that, owners Chad and Liz are very friendly and helpful. Highly recommended!
Guest favorite
A serene landscape captures a pond surrounded by lush greenery and towering pine trees. A small dock extends over the water, and a gazebo is visible in the distance, providing shaded seating. Open grassy areas invite relaxation and exploration.
Guesthouse in Vero Beach
4.99 out of 5 average rating, 84 reviews

Cottage in Vero Beach

JosephRating, 5 stars5 months ago
A very private and well laid out location, the cottage is very homey and the grounds with the pond were very relaxing, I would stay here again.
A serene sunset view over the river is framed by swaying palm trees. Soft pink and purple hues blend in the sky, reflecting on the water's surface. The landscape offers a peaceful ambiance, making it ideal for relaxation and enjoying nature.
Guesthouse in Fort Pierce
4.67 out of 5 average rating, 12 reviews

Indian River Getaway

SheriRating, 5 stars1 month ago
Shane's place was perfect for our stay. Old Florida charm and very clean. We enjoyed sitting by the river and watching the sunsets. In town to visit relatives, so didn't spend a lot of time cooking, but unit had all of the amenities to do so. If there was any negative, it was that GPS brought us in down several miles of 25 mph road, however, we quickly found an alternative route the next day that made the commute to the main road much faster, although, the route along the river is beautiful.

Guest house rentals with a patio

Guest favorite
A serene view of the waterway is presented from a wooden railing. Lush trees line the banks, reflected on the calm surface of the water, while boats are anchored along the dock in the distance, creating a peaceful natural atmosphere.
Guesthouse in Palm City
4.95 out of 5 average rating, 22 reviews

New Waterfront Hideaway Studio!

DavidRating, 5 stars1 week ago
We thoroughly enjoyed our stay! The hideaway was delightful and the outdoor space was very relaxing! I enjoyed my morning coffee overlooking the canal. What a great start to each day! Renata couldn’t have been a more gracious host! She made us feel so welcome.
Top guest favorite
The image features a designer-decorated bedroom with a comfortable bed adorned in soft linens. A decorative table holds fresh flowers, almonds, and apples, while a cozy area rug enhances the room's warmth.
Guesthouse in Fort Pierce
5 out of 5 average rating, 43 reviews

Casita Luna - Sunny boho retreat with a pool

ArmandoRating, 5 stars5 days ago
Place was perfect. Peaceful, clean and the pool was great
Superhost
A bright sleeping area features a spacious bed dressed in white linens, complemented by decorative pillows. A textured throw is laid across the foot of the bed. Two folding chairs are positioned at the foot, with a woven storage unit and wall art enhancing the cozy ambiance.
Guesthouse in Port St. Lucie
4.79 out of 5 average rating, 24 reviews

Private entrance,1bdroom, kitchen,sitting area

tomRating, 5 stars1 month ago
I can't say enough good things about Jeanette and her place. She should train other hosts about how to host us travelers. She responded to my questions within minutes. Her place was exactly what we wanted. We especially enjoyed the privacy of the courtyard. We hoped to come to Florida again next winter and we would definitely hope Jeanette's place would be available. We've enjoyed some very good stays with airbnb but Jeanette is at the top of the list!
Top guest favorite
An outdoor seating area features a wooden table surrounded by four chairs. Potted plants provide greenery, while a vibrant yellow pouf adds a pop of color. Light blue walls and a white door frame the space, creating a relaxed and inviting atmosphere.
Guesthouse in Vero Beach
5 out of 5 average rating, 37 reviews

The Bonita Bungalow

RachelRating, 5 stars3 weeks ago
We had a wonderful time! We loved the close commute to the beach, hanging at the pool, and all the plants!
Top guest favorite
Guesthouse in Port St. Lucie
4.96 out of 5 average rating, 71 reviews

Private apt. for 4, king bed, laundry inside.

KenRating, 5 stars3 days ago
Highly recommended….was everything it said it would be in the description. Clean, quiet and safe. Great Host.
Top guest favorite
Guesthouse in Hobe Sound
4.98 out of 5 average rating, 63 reviews

Adorable 1 bed/bath just 1 mile to the beach.

SaraRating, 5 stars3 weeks ago
This home was so clean and cozy, we actually spent more time at it than we anticipated because it was that nice! Super safe neighborhood and a lot of restaurants we could walk to. Can’t wait to come back!
Superhost
A bright and airy bedroom features an oversized bed with patterned bedding. Colorful walls in orange and turquoise complement the wood flooring. Natural light enters through two windows, each adorned with bamboo shades. A cozy chair and a textured area rug add to the inviting decor.
Guesthouse in Fort Pierce
4.83 out of 5 average rating, 6 reviews

surf shack

ChristineRating, 5 stars1 month ago
The Surf Shack was the ideal place for my week stay in Fort Pierce! The location was perfect for what I was in town for and also very close to the beach, downtown, and anything else I needed. It was a cozy and comfortable place to come home to after a long and busy day and had everything I needed. Will definitely see if it is available if I am in town again next year.
Top guest favorite
A comfortable living area is furnished with a large sectional couch adorned with decorative pillows. A glass coffee table sits in the center, complemented by a small green plant. Natural light fills the space through a curtain-draped window, while a flat-screen TV is mounted on the wall.
Guesthouse in Port St. Lucie
5 out of 5 average rating, 40 reviews

Coastal Retreat

JamieRating, 5 stars2 days ago
We stayed at Gina's place while visiting family. We needed somewhere clean and comfy to lay our heads and this was great! She had all the things if you wanted to cook, the coffee was great, the shower was pretty and had good water pressure. Our 12 year old daughter slept comfortably on the sofa and there were extra blankets and towels. Would stay again 😊

Guest house rentals with a washer and dryer

Top guest favorite
A charming detached garage is set among landscaped greenery, featuring a light blue exterior and white roof. The main house is visible in the background, surrounded by palm trees and well-maintained grass, creating a serene outdoor atmosphere.
Guesthouse in Palm City
4.88 out of 5 average rating, 24 reviews

Charming Guest Efficiency

JeffreyRating, 5 stars1 month ago
Located in a nice quiet neighborhood and Kerrie was attentive to our needs. Common outdoor space was nice but too cold to utilize.
A well-arranged bedroom features a spacious queen bed topped with soft pillows and a decorative quilt. A cozy blue sofa offers additional seating. Natural light filters through a nearby window and a full-length mirror reflects the room's layout, complemented by light-colored walls and flooring.
Guesthouse in Fort Pierce
5 out of 5 average rating, 3 reviews

Guesthouse by the Beach

jerryRating, 5 stars1 month ago
Love her place. Quiet neighborhood. The unit was nicely appointed, modern and clean.
Guest favorite
Guesthouse in Stuart
4.97 out of 5 average rating, 38 reviews

The Eight Legged Sailor, Downtown Stuart, Boating

RickRating, 5 stars3 weeks ago
This was our third stay at Lindie's place and in the words of my wife, it has become "our home away from home". I won't repeat our prior reviews (they still apply) but will note that Lindie always seems to add nice little touches to the cottage with continual improvement. This year we noticed new wall decorations, a new Dyson sweeper, outside painting and new patio chairs. I shows her commitment to always making your stay a little more enjoyable. Thanks Lindie!
Guest favorite
A wooden trellis adorned with vibrant foliage frames a meandering pathway. Colorful plants flourish alongside the path, leading to a pool area visible through a screen. Sunshine filters through the leaves, creating a serene atmosphere in this lush outdoor space.
Guesthouse in Vero Beach
5 out of 5 average rating, 36 reviews

Comfy Heated Pool Cottage with home office

MaryRating, 5 stars1 month ago
Lisa's place was perfect, it was clear that a lot of intention was put into making it a delightful place to stay, from the thoughtful snacks and treats to being stocked with everything you need for a long stay. Lisa was very responsive and checked in to make sure I had everything I needed. The cottage is fresh, clean and full of light. I swam in the heated pool every morning. And the grounds are lush and beautiful. It was a wonderful experience staying at Lisa's and I will do it again!
Guest favorite
The exterior of a two-story building is showcased, surrounded by lush greenery and palm trees. A well-maintained lawn is visible, with a paved driveway leading to the entrance. Soft evening lighting highlights the architectural details, offering a serene and inviting atmosphere.
Guesthouse in Fort Pierce
4.91 out of 5 average rating, 32 reviews

1 Bed Studio Pet & Boat OK Near Marina & Beach

NhungRating, 5 stars1 month ago
So thankful to have found Bill's spot! Looking around the area as there weren't too many good options for hotels and hopped on Airbnb to try my luck. Great safe neighborhood and very close to where we needed to be for a wedding. Wonderful stay!
An industrial-style interior features exposed brick walls and large windows allowing natural light. A spacious upper level overlooks brewing equipment with a railing, while wooden tables and chairs are arranged for dining. The atmosphere is complemented by hanging light fixtures and polished wooden flooring.
Guesthouse in Vero Beach
4.92 out of 5 average rating, 151 reviews

Renovated 1/1 Guest House Apartment -Pets Welcome!

TinaRating, 5 stars17 months ago
Our stay with Josh couldn't have been better! He welcomed us upon arrival and was so friendly, welcoming and helpful. His apartment was an absolutely delightful beach cottage apartment in a quite, peaceful, walkable, convenient neighborhood. He had everything and more we might have needed in his apartment and it was so clean and comfortably cozy. With it's central location we were within 5-20 minutes of everything we wanted to do on our Southern Adventure. Josh was the perfect balance of proactive host yet giving us our space to come and go freely. We would absolutely stay at Josh's again should we find ourselves in Vero Beach again. Great place! Terrific host!
Guest favorite
The exterior view of the two-story unit is framed by lush tropical vegetation. A light-colored building structure features a balcony above and a welcoming entrance below. A pair of outdoor chairs is positioned near the entrance, inviting relaxation amid the greenery.
Guesthouse in Fort Pierce
4.9 out of 5 average rating, 52 reviews

Tropical Beach Destination | Steps to the Beach!

DonaldRating, 5 stars3 weeks ago
Amy’s place was right across the road from beach access. Perfect spot for 1-2 people. I stayed here while my son played baseball in Vero Beach and it was about a 30 minute drive through side streets. Probably only down side had nothing to do with property but area. Most all restaurants closed before 8-9 so either plan to eat early or use the kitchen as an option at the property. Everything in the area is walkable
Guest favorite
A tranquil canal scene is depicted at sunset, with a thatched-roof hut and lush palm trees framing the waterway. A lounge chair is positioned on the dock, inviting relaxation while reflecting the vibrant colors of the sky.
Guesthouse in Port St. Lucie
4.86 out of 5 average rating, 43 reviews

Cozy River Retreat

MarisolRating, 5 stars1 week ago
Thank you for everything fabulous place. We appreciate you

Quick stats about guesthouse rentals in Port St. Lucie

  • Total rentals

    20 properties

  • Nightly prices starting at

    $50 before taxes and fees

  • Total number of reviews

    1.1K reviews

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wifi availability

    20 properties include access to wifi

  • Popular amenities

    Kitchen, Wifi, and Pool

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