
Vacation rentals in Clayton
Book unique vacation rentals, houses, and more on Airbnb
Top-rated vacation rentals in Clayton
Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Clayton vacation rentals
Other great vacation rentals in Clayton

Florissant's Old Town Inn (3BR)
What a treasure we stumbled across! If you enjoy the vibes of an older home this one is for you! The neighborhood is very safe and amazing! The actual home has glass door knobs (if you know you know). The antique ceiling lights are amazing. They do have electronic locks, which are easy to access. The baths are updated, as well as the kitchen. Everything you could need was provided. We rented the entire place, (upstairs and down). My husband and I enjoying a weekend to watch some Cardinals baseball with our two adult children and a granddog. Sitting on the back patio watching the Koi fish could not have been more relaxing. Thanks for a great adventure. I hope to be able to visit this home in the future.

Becky's Oasis-Sleeps 6/3 beds/Ballwin MO
Becky was very helpful and responsive. The house was convenient to the airport and nearby shopping.

Perfect Getaway 3BR/3BA Home
Wonderful stay. The place was easy to access and exactly as described. The host was friendly and responsive. Would definitely stay again.

Cheerful one bedroom cottage on a horse farm
It was so nice to get away and relax for the night at the cottage! It was so peaceful! Water pressure in the shower was amazing and the bed was so comfortable! Will definitely stay again!

We do Italian STL style. Perfecto! Enjoy our NBHD!
This was the perfect spot… peaceful, safe, and quiet neighborhood within walking distance of so many homey, welcoming local restaurants! It was lovely to be able to walk everywhere to dinner and not have to drive. And it was within easy driving distance of all the tourist stuff we wanted to do. The suite had everything we needed and we especially appreciated the labels on the light switches! Very clean and comfy. Would 100% stay here again.

Modern Luxury w/Saltwater Pool / ABODEbucks
Had a wonderful stay at this Airbnb! The place was exactly as described—clean, comfortable, and thoughtfully decorated. The host was incredibly welcoming and responsive, making sure everything went smoothly. The location was perfect for exploring the area, and I truly felt at home during my stay. I would absolutely stay here again and highly recommend it to anyone looking for a relaxing and enjoyable visit! The work room was a plus.

Centrally Located Family Home - Park Like Yard
One of the best places that I've ever stayed! It was excellent! Will stay again, if needed!

Quiet St Charles Cottage w/ Patio & 4 Acres
Had a great stay here, was very warm and cozy plenty of space especially if you’re traveling alone… Anita was very useful with plenty of instructions and great communication about the property.. I would highly recommend a stay here
Quick stats about vacation rentals in Clayton
Total rentals
30 properties
Nightly prices starting at
$50 before taxes and fees
Total number of reviews
1.4K reviews
Family-friendly rentals
20 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
20 properties have a dedicated workspace
Frequently Asked Questions
Where should I stay in Clayton?
Make yourself at home in Clayton by choosing from our most frequently booked neighborhoods. We have over 310 vacation rentals in Wydown Skinker, and over 310 vacation rentals in Downtown Clayton.
How much does it cost to stay in apartment rentals in Clayton?
Experience the best of Clayton with our apartment rentals, starting at about $50 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there apartment rentals with a dedicated workspace in Clayton?
Yes! Work meets play with ease at over 10 apartment rentals in Clayton featuring dedicated workspaces. Stay connected and productive in your home away from home.
Are there pet-friendly vacation rentals in Clayton?
Four-legged friends are welcome in Clayton. Choose from more than 10 vacation rentals for guests traveling with pets.
Do apartment rentals in Clayton have wifi?
Absolutely! We offer over 20 apartment rentals with wifi in Clayton. Enjoy a tailored experience with all the comforts you desire.
Are there family-friendly apartment rentals in Clayton?
Clayton has more than 10 family-friendly apartment rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
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- Busch Stadium
- Enterprise Center
- Six Flags St. Louis
- Saint Louis Zoo
- Central West End
- Gateway Arch National Park
- Missouri Botanical Garden
- City Museum
- St. Louis Aquarium at Union Station
- Saint Louis Science Center
- Castlewood State Park
- Hidden Valley Ski Resort
- Missouri History Museum
- Pere Marquette State Park
- Cuivre River State Park
- Cathedral Basilica of Saint Louis
- Adventure Valley Zipline Tours and Paintball Park
- St. Louis Country Club
- The Winery at Aerie's Resort
- Raging Rivers WaterPark
- Grafton Winery the Vineyards
- Boone Valley Golf Club
- Old Warson Country Club
- Bellerive Country Club
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