Guesthouse vacation rentals in South Carolina
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Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Greenville
4.92 out of 5 average rating, 590 reviewsHistoric 19th Century Cabin/Guest House
Guesthouse in Townville
4.88 out of 5 average rating, 232 reviewsLisa’s Lodge
Guesthouse in Salem
4.88 out of 5 average rating, 291 reviewsMountain Edge Loft
Guesthouse in Charleston
4.92 out of 5 average rating, 309 reviewsMother in Law in James Island Riverland Terrace
Guesthouse in Beaufort
4.94 out of 5 average rating, 398 reviewsMeridian Rd. Guest House Walk to Restaurants/Parks
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 223 reviewsPrivate Studio Apt - (Pets/beach/pool/golf)
Guesthouse in Camden
4.94 out of 5 average rating, 182 reviewsRed Roof Loft @ FireFly Farm
Guesthouse in Ridgeville
4.82 out of 5 average rating, 215 reviewsPond House Bungalow at Natural Gathering Grounds
Guest house rentals with a patio
Guesthouse in Abbeville
4.95 out of 5 average rating, 109 reviews1-bedroom guesthouse in Abbeville, SC
Guesthouse in Charleston
4.93 out of 5 average rating, 178 reviewsQuaint Cottage Studio in Ashley Forest (Avondale)
Guesthouse in North Charleston
5.0 out of 5 average rating, 115 reviewsThe Park Circle Clerestory Studio Guest House
Guesthouse in Johns Island
4.91 out of 5 average rating, 115 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Columbia
4.95 out of 5 average rating, 151 reviewsRenovated One Bedroom Guest House by UofSC
Guesthouse in Charleston
4.96 out of 5 average rating, 132 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Charleston
4.98 out of 5 average rating, 129 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Spartanburg
5.0 out of 5 average rating, 46 reviewsThe Lodge at Pythian Park
Guest house rentals with a washer and dryer
Guesthouse in Westminster
4.99 out of 5 average rating, 151 reviewsLit'l Bit O' Heaven- Rocky Top Lodge
Guesthouse in Abbeville
4.99 out of 5 average rating, 150 reviewsModern Carriage House
Guesthouse in Florence
4.99 out of 5 average rating, 678 reviewsBoho Private Downtown Stay Near I-95 & Hospital
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 413 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Guesthouse in Camden
4.91 out of 5 average rating, 275 reviewsCamden Coach House Long term stay southern balance
Guesthouse in Florence
4.93 out of 5 average rating, 138 reviewsMidtown Retreat - Guest House in heart of Florence
Guesthouse in Summerville
4.97 out of 5 average rating, 221 reviewsTiny Oak Cottage in Historic Downtown Summerville
Guesthouse in Charleston
4.99 out of 5 average rating, 264 reviewsSpacious Daniel Island Apartment
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