Guesthouse vacation rentals in South Carolina
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Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Salem
4.88 out of 5 average rating, 292 reviewsMountain Edge Loft
Guesthouse in Townville
4.88 out of 5 average rating, 232 reviewsLisa’s Lodge
Guesthouse in West Columbia
4.94 out of 5 average rating, 607 reviewsCarriage House: Studio Bed & Bath - Pool & Hot Tub
Guesthouse in Ridgeville
4.82 out of 5 average rating, 215 reviewsPond House Bungalow at Natural Gathering Grounds
Guesthouse in Beaufort
4.94 out of 5 average rating, 400 reviewsMeridian Rd. Guest House Walk to Restaurants/Parks
Guesthouse in Charleston
4.92 out of 5 average rating, 311 reviewsMother in Law in James Island Riverland Terrace
Guesthouse in Camden
4.94 out of 5 average rating, 182 reviewsRed Roof Loft @ FireFly Farm
Guesthouse in Greenville
4.92 out of 5 average rating, 592 reviewsHistoric 19th Century Cabin/Guest House
Guest house rentals with a patio
Guesthouse in Abbeville
4.95 out of 5 average rating, 111 reviews1-bedroom guesthouse in Abbeville, SC
Guesthouse in Charleston
4.93 out of 5 average rating, 179 reviewsQuaint Cottage Studio in Ashley Forest (Avondale)
Guesthouse in Charleston
4.96 out of 5 average rating, 133 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Johns Island
4.91 out of 5 average rating, 116 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Charleston
4.98 out of 5 average rating, 132 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Charleston
4.83 out of 5 average rating, 100 reviewsGuest Suite by the Beach
Guesthouse in Columbia
4.95 out of 5 average rating, 151 reviewsRenovated One Bedroom Guest House by UofSC
Guesthouse in Spartanburg
5.0 out of 5 average rating, 46 reviewsThe Lodge at Pythian Park
Guest house rentals with a washer and dryer
Guesthouse in Beaufort
4.98 out of 5 average rating, 211 reviewsBuddy's Cottage near everything in Beaufort, SC
Guesthouse in Westminster
4.99 out of 5 average rating, 151 reviewsLit'l Bit O' Heaven- Rocky Top Lodge
Guesthouse in Camden
4.91 out of 5 average rating, 279 reviewsCamden Coach House Long term stay southern balance
Guesthouse in Summerville
4.97 out of 5 average rating, 221 reviewsTiny Oak Cottage in Historic Downtown Summerville
Guesthouse in Donalds
4.99 out of 5 average rating, 347 reviewsHome on the farm
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 415 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Guesthouse in Florence
4.99 out of 5 average rating, 682 reviewsBoho Private Downtown Stay Near I-95 & Hospital
Guesthouse in Bluffton
4.97 out of 5 average rating, 459 reviewsCharming Carriage house
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