Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Mansion rentals with a pool
Home in San Carlos
4.93 out of 5 average rating, 89 reviewsBeach House-Ocean View Rooftop Jacuzzi & Pool
Villa in Panamá
5.0 out of 5 average rating, 32 reviewsBreathtaking Views Mansion w/King Beds
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsSpectacular beachfront house in Buenaventura!
Villa in Panamá
4.98 out of 5 average rating, 49 reviewsBeautiful House in Panama w/ King Beds + Pool
Home in Playa Bluff
5.0 out of 5 average rating, 18 reviewsJungle House 100m from the beach
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Condo in Maria Chiquita
5.0 out of 5 average rating, 22 reviewsPlaya Escondida Lux Beachfront Haven:Oceanview Apt
Villa in Buenaventura, El Chirú
4.84 out of 5 average rating, 45 reviewsLake House | Pool | King Beds | Next to Beach Club
Luxury mansion rentals
Apartment in Panama City
4.84 out of 5 average rating, 31 reviewsPenthouse deluxe, 360º views and glass pool
Home in Gamboa
4.86 out of 5 average rating, 88 reviewsBirdHouse@ Gamboa Panamá Canal
Apartment in Maria Chiquita
4.95 out of 5 average rating, 63 reviewsSpacious 4Br Beachside Getaway at Playa Escondida
Apartment in Maria Chiquita
4.95 out of 5 average rating, 21 reviewsPenthouse in Playa Escondida 4 bedrooms
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
Villa in Punta Chame
4.92 out of 5 average rating, 13 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
Villa in Río Hato
4.91 out of 5 average rating, 22 reviewsSecluded Villa in Buenaventura Golf and Resort
Villa in Bocas del Toro
5.0 out of 5 average rating, 11 reviewsCasa de Mono Jungle Villa by the Beach
Pet-friendly mansion rentals
Home in Panamá
5.0 out of 5 average rating, 11 reviewsWonderful House with Terrace and Sea View
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Home in San José
5.0 out of 5 average rating, 21 reviewsαlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Villa in Costa Esmeralda
5.0 out of 5 average rating, 15 reviewsSpectacular 600-meter oceanfront beach house
Villa in Costa Esmeralda
4.97 out of 5 average rating, 71 reviews#1 Villa with pool, jacuzzi, pool table, ping pong.
Home in Pedasí
4.83 out of 5 average rating, 6 reviewsOcean View From The Jungle!
Apartment in El Chirú
4.94 out of 5 average rating, 85 reviewsBuenaventura Golf & Beach Resort Lux Apartment
Cabin in Volcán
5.0 out of 5 average rating, 23 reviewsWhole 4 Bed Cabin/ Highlands/Chiriqui
Destinations to explore
- Loft rentals Panama
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