Vacation rentals in Defiance

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Top-rated vacation rentals in Defiance

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Guest favorite

Tiny home in Pacific

4.95 out of 5 average rating, 177 reviews

Route 66 railroad shanty, a cozy artsy small space

This 536 s.f. house, believed to have once been a sleeping shanty for railroad crews switching shifts for the night. Fully renovated and updated in 2021 by a local artist, you will find custom metal art throughout, granite countertops and a very warm cabin feel featuring a kitchen and bathroom finished with locally sourced Missouri dark red cedar, 10 minutes from six flags, Purina farms 15 min from hidden valley and 45 min from downtown this place is in a great location and will not disappoint!

Guest favorite

Home in St. Peters

4.88 out of 5 average rating, 319 reviews

Private Walkout w King Bed & Bath + large livingrm

Our house sits in a very quiet and safe neighborhood. When you stay with us you will enter through the walkout basement. You have full access to our very private downstairs apartment. This will enter you right into the very large living area. The master bedroom is complete with a King bed, black out curtains and walk-in closet. Attached is a full size bathroom with walk-in shower. Amenities include television, DVD, WiFi, Kuerig, mini-fridge and access to patio/porch with backyard fire pit.

Guest favorite

Home in Augusta

4.99 out of 5 average rating, 224 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 506 reviews

301 Guesthouse SuperHost/Shop Discounts/Katy Trail

Our 301 Guest House is new and completely remodeled in 2018! It’s ideal for one or two people with beautiful furnishings, great queen bed, lots of amenities, full kitchen, with big back yard and patio to enjoy outdoors too! Cable and FAST WiFi! Enjoy light Breakfast! BEST location, Great events year round within walking distance, with being only about 2 blocks from S. Main St, where there are about 100 gift shops n restaurants! Katy Trail is so close, with Spring, Summer, Fall and Xmas events!

Guest favorite

Cabin in Defiance

4.95 out of 5 average rating, 112 reviews

Hillside Cabin on 43 Acres w/ Private Lake & View!

Free from modern distractions, this 1-bedroom, 1-bath cabin in the heart of wine country is the perfect place to unplug and reconnect with nature! Immersed in lush woodlands, the Defiance vacation rental comes with all the amenities needed for a peaceful retreat, including a fishing lake, resident horses, and a fully equipped kitchen. Watch the sunrise over the hills from the porch swing before venturing off to Katy Trail, and later, head to Chandler Hill Vineyards located just minutes away!

Superhost

Tiny home in Pacific

4.9 out of 5 average rating, 502 reviews

Route 66 Cozy Cottage

* Fast Wifi (Spectrum) * Keypad entry (no keys to keep track of) * Private driveway by the front door for easy access to carry luggage in and out * Huge yard for dogs, kids or even adults to play * Lovely outdoor patio with plenty of comfortable seating and beautiful landscaping * For the kiddos- fun, colorful plastic dinnerware, toys, books, puzzles, and games (puzzles and games for adults too) * Essentials for your furbabies as well - treats, leashes, food & water bowls, waste bags, towels

Guest favorite

Home in Saint Charles

4.97 out of 5 average rating, 187 reviews

Bright & Cozy Shotgun DPX 1 Block from Historic DT

Admire this unique historic home's design with brand new amenities and antique details that give a fresh and charming feel. Built in the 1930's, this half of the duplex has a typical shotgun layout with ten-foot ceilings giving a spacious feel. The front door leads directly to the living room, then into the bedroom, both of which have the original hard wood floors. The back of the house has the kitchen, with exposed brick, a dining area, and a bathroom with a washer and dryer.

Guest favorite

Farm stay in Grafton

4.97 out of 5 average rating, 213 reviews

Pere Ridge Tree Escape

Welcome to Pere Ridge ! Enjoy the lovely setting of this romantic spot in nature. Pere Ridge is a custom Scandinavian inspired nature escape for two . Our elevated cabin is perched on a ridge with a deck and hot tub that is surrounded by trees. Our hope is that you disconnect from life's stresses while at Pere Ridge. Our cabin is located in "the ridge " area of Grafton and is a short drive to Grafton. It is a light filled studio cabin with modern touches .

Guest favorite

Guesthouse in Marthasville

4.96 out of 5 average rating, 228 reviews

Hazel's House by the Katy Trail

In the heart of Missouri Wine Country. Within walking distance of the Katy Trail and Lake Creek Winery. Many wineries within a 25-30 minute drive. Enjoy a weekend getaway in a 2 bed 1 bath home. Hazel's House is clean, comfortable and private overnight accommodations. We are not a bed and breakfast, no food included, but there is coffee. Please make sure the location is suitable. We are located out in the country and the internet can be spotty.

Guest favorite

Home in Dittmer

4.95 out of 5 average rating, 367 reviews

Honeymoon Suite Camp Skullbone In The Woods

Romantic quiet cozy chalet for two! Vintage décor with all the modern amenities of home. Relax inside to unwind, kick back and watch a movie, surf the web via free wi-fi, curl up with a good book, open up a board game for a friendly challenge or share a drink with that special someone. Want some fresh country air? Lace-up those hiking boots and take like Camp Skullbones. . Enjoy the stars on the intimate deck with the glow from the gas fire pit.

Guest favorite

Loft in Washington

4.99 out of 5 average rating, 309 reviews

2nd Street Loft - Riverview

Complete Rehab, this historic 1883 storefront building hosts a well known artist and his gallery on the 1st floor. Above is your "loft space" close to wineries, Amtrak, featuring great views of the Missouri River. You’ll love this Downtown Washington location because of the walkable shops, bars, and restaurants many in historic buildings. The loft is great for couples, solo adventurers, and business travelers who can walk a flight of stairs.

Guest favorite

Cabin in Hillsboro

4.93 out of 5 average rating, 101 reviews

The Shagbark Hickory (Hot Tub & Sauna)

Take it easy at this unique and tranquil getaway. Enjoy a detox in our handcrafted sauna, or take a soak in the hot tub under the stars! Full kitchen, bathR w/claw foot, & screened in porch. It’s very private, with land to explore. Take a stroll to the pond or creek or book a massage with our own licensed Massage therapist! Close to La Chance winery, Desoto town, Big River access points, valley view glades, & Washington state park.

Vacation rentals for every style

Get the amount of space that is right for you

Popular amenities for Defiance vacation rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Stay near Defiance's top sights

August A. Busch. Memorial Conservation Area4 locals recommend

Historic Daniel Boone Home15 locals recommend

Montelle Winery18 locals recommend

Chandler Hill Vineyards15 locals recommend

Weldon Spring Conservation Area3 locals recommend

Klondike Park14 locals recommend

Other great vacation rentals in Defiance

Guest favorite

Home in Saint Charles

4.88 out of 5 average rating, 556 reviews

The Benton House - With fenced yard!

Guest favorite

Farm stay in Lake Saint Louis

4.92 out of 5 average rating, 198 reviews

Updated Farmhouse 2 bd 2 acres

Guest favorite

Guest suite in Saint Charles

4.95 out of 5 average rating, 309 reviews

Creekside Suite - Peaceful, Spacious, and Comfy

Guest favorite

Home in St. Peters

4.94 out of 5 average rating, 124 reviews

Comfy 3BR home in heart of Saint Peters

Guest favorite

Cabin in St Charles

4.98 out of 5 average rating, 301 reviews

Camp Mill Pond: Historic Cabin Near Main Street

Guest favorite

Home in Augusta

5.0 out of 5 average rating, 110 reviews

Augusta Haus

Guest favorite

Cabin in Innsbrook

4.94 out of 5 average rating, 163 reviews

Squirrel Run at Innsbrook Resort

Guest favorite

Cottage in Augusta

4.9 out of 5 average rating, 50 reviews

Romantic Augusta Cottage-Relax & get away!

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Quick stats about vacation rentals in Defiance

Total rentals
10 properties
Local attractions
Chandler Hill Vineyards, August A. Busch. Memorial Conservation Area, and Weldon Spring Conservation Area
Popular amenities
Kitchen, Wifi, and Pool
Wifi availability
10 properties include access to wifi
Total number of reviews
560 reviews
Nightly prices starting at
$70 before taxes and fees

Vacation rentals in Defiance

Top-rated vacation rentals in Defiance

Tiny home in Pacific

Home in St. Peters

Home in Augusta

Home in Saint Charles

Cabin in Defiance

Tiny home in Pacific

Home in Saint Charles

Farm stay in Grafton

Guesthouse in Marthasville

Home in Dittmer

Loft in Washington

Cabin in Hillsboro

Vacation rentals for every style

Hotels

Unique stays

Homes

Popular amenities for Defiance vacation rentals

Stay near Defiance's top sights

Other great vacation rentals in Defiance

Home in Saint Charles

Farm stay in Lake Saint Louis

Guest suite in Saint Charles

Home in St. Peters

Cabin in St Charles

Home in Augusta

Cabin in Innsbrook

Cottage in Augusta

Quick stats about vacation rentals in Defiance

Total rentals

Local attractions

Popular amenities

Wifi availability

Total number of reviews

Nightly prices starting at

Destinations to explore